https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52182 Wed 04 Oct 2023 11:03:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41153 Thu 28 Jul 2022 09:20:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48410 Thu 16 Mar 2023 14:03:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7715 10% change in sputum neutrophils using Illumina Humanref-8 expression microarrays. There were 104 genes differentially expressed following the dietary change. Upregulated genes were involved in the innate immune response and included the innate immune receptors TLR2, IL1R2, CD93, the signaling molecules IRAK2, IRAK3, and neutrophil proteases MMP25 and CPD. Downregulated genes included those involved in endogenous antioxidant defenses (GSTA1, GSTA2) and protease inhibition (SLPI, SERPINB3). Altered expression of five genes (TLR2, IRAK2, IL1R2, C20orf114, and SERPINB3) was confirmed using real-time polymerase chain reaction (PCR). These observations suggest that depletion of dietary antioxidants in asthma may result in upregulation of genes involved in the innate immune response. A diet low in antioxidants may be contributing to the development of neutrophilic asthma through activation of the innate immune response.]]> Sat 24 Mar 2018 08:41:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19962 Sat 24 Mar 2018 07:58:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19788 cell proliferation (FKPB1A, HDGF, MIF, PRDX1, TXNRD1, LGALS1, STMN1, LASP1, S100A11, S100A6), survival (HSPE1, HSPB1, HSPD1, HSPA5 and PPIA, YWHAZ, CFL1, NME1) and motility (CFL1, CORO1B, PFN2, PLS3, FLNA, FLNB, NME2, ARHGDIB). In view of the pleotropic effects of PFN1 overexpression in breast cancer cells as suggested by these new findings, we propose that PFN1-induced phenotypic changes in cancer cells involve multiple mechanisms. Our data reported here might also offer innovative strategies for identification and validation of novel therapeutic targets and companion diagnostics for persons with, or susceptibility to, breast cancer.]]> Sat 24 Mar 2018 07:57:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39770 Mon 25 Jul 2022 10:45:46 AEST ]]>